Inhibiting the Evolution of Antibiotic Resistance
نویسندگان
چکیده
منابع مشابه
The “ Evolution ” of Antibiotic Resistance
An increase in the frequency of antibiotic resistance in bacteria since the 1950s has been observed for all major classes of antibiotics used to treat a wide variety of respiratory illnesses, skin disorders, and sexually transmitted diseases. Is this resistance the result of bacteria evolving new genes in response to the presence of antibiotics, or are antibiotic-resistant bacteria selected for...
متن کاملEvolution of Antibiotic Resistance
Pietsch, F. 2015. Evolution of Antibiotic Resistance. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1150. 67 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9380-6. The emergence of antimicrobial resistance is a major global threat to modern medicine. The rapid dissemination of resistant pathogens and the associated loss of efficacy of many i...
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Antibiotic use is the main driver in the emergence of antibiotic resistance. Another unexplored possibility is that resistance evolves coincidentally in response to other selective pressures. We show that selection in the absence of antibiotics can coselect for decreased susceptibility to several antibiotics. Thus, genetic adaptation of bacteria to natural environments may drive resistance evol...
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15 صفحه اولDisrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase.
Conjugative transfer of plasmid DNA via close cell-cell junctions is the main route by which antibiotic resistance genes spread between bacterial strains. Relaxases are essential for conjugative transfer and act by cleaving DNA strands and forming covalent phosphotyrosine linkages. Based on data indicating that multityrosine relaxase enzymes can accommodate two phosphotyrosine intermediates wit...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2019
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2018.10.015